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If methotrexate makes your child sick, ask your doctor about prescribing ondansetron zofran , a drug that blocks the signal in the brain that causes nausea and vomiting.

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Ondansetron is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancerchemotherapy or radiation

While doxylamine/pyridoxine is the only FDA-approved medication for morning sicknessdoctors continue to write off-label prescriptions for other medicationsFirst-line alternatives include antihistamines diphenhydramine and meclizinewhich were deemed Pregnancy Risk Category Blike Zofran.

Ondansetron is extensively metabolized in humanswith approximately 5of a radiolabeled dose recovered as the parent compound from the urineThe metabolites are observed in the urineThe primary metabolic pathway is hydroxylation on the indole ring followed by subsequent glucuronide or sulfate conjugation.

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usually, the symptoms respond to an anti motion-sickness drug such as meclizine antivert, bonine, or dramamine ; , the newer skin patches that deliver scopolamine, or the anti-nausea drug ondansetron zofran ;.

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